Antibody Engineering and Expression Services

At Oxford Genetics we have expertise in engineering and expressing a wide range of recombinant antibody formats and we now offer expression optimization and research grade production services. Recombinant antibody production is carried out in biologically defined, serum-free, mammalian expression systems to produce high-purity recombinant antibodies with potential diagnostic and therapeutic applications.

Oxford Genetics recombinant optimization and expression services include bioinformatic analysis, codon optimization and synthesis of antibody constructs (e.g. full-length mAb, chimeric mAb, humanized mAb, Fab/ScFv), cloning into expression plasmids, transient transfection, antibody production, and process development.

 

Gene Cloning and Expression Optimization

Project Design

Included

DNA Optimization

Codon Optimization

(Propriety Algorithm and Curated)

DNA Synthesis

Included

Custom Cloning

Oxford Genetics Propriety Plasmid

or Customer Supplied Plasmid

Analytics

SDS-PAGE

Western Blot

ELISA

HPLC

Turnaround Time

2 to 3 weeks

 

 

Research Grade Protein Expression and Purification

Scale

Up to 5 mg

Up to 10 mg

Up to 20 mg

Up to 30 mg

Up to 50mg

Purification

Protein A or G

Protein A or G

Protein A or G

Protein A or G

Protein A or G

Analytics

SDS-PAGE

Western Blot

ELISA

HPLC

SDS-PAGE

Western Blot

ELISA

HPLC

SDS-PAGE

Western Blot

ELISA

HPLC

SDS-PAGE

Western Blot

ELISA

HPLC

SDS-PAGE

Western Blot

ELISA

HPLC

Turnaround Time

2 to 3 weeks

2 to 3 weeks

2 to 3 weeks

2 to 3 weeks

2 to 3 weeks

 

 

 

 Additional Services

Cell Line Engineering

Oxford Genetics has expertise engineering mammalian cell lines using a variety of technologies including gene editing.

Cell Line Development

Oxford Genetics has expertise generating stable, recombinant, cell lines expressing heterologous products, such as proteins or viruses.