Associate Scientist - Protein Expression

 

JOB TYPE: Permanent
HOURS: Full time
SALARY: £20,000 – £28,000/pa, dependent on experience

 

ABOUT OXFORD GENETICS:

Oxford Genetics, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford.

We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists, engineers and technicians to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do – join us and contribute to this exciting journey!

 

ROLE OVERVIEW:

The Associate Scientist – Protein Expression will work as part of an internal function for the generation and characterisation of recombinant proteins for in-vitro applications. The appointee will work with Scientist and Senior Scientist colleagues to expand these services and offerings within the company. This function sits within the Protein Therapeutics business unit which encompasses antibody discovery, protein engineering and expression, and cell line development. 

Prior experience working in a laboratory environment is essential, as is familiarity with working to SOPs and producing batch records. Relevant techniques include plasmid preparation, mammalian cell culture and transfection (suspension), harvest/clarification, purification of proteins using PrA/AEX chromatography, and characterisation by HPLC, ELISA and SDS-PAGE. Training will be provided but prior experience in these areas would be advantageous.

 

KEY RESPONSIBILITIES:

  • Work closely with internal and external stakeholders to define project goals and deliverables, in line the planned project objectives
  • Provide project summaries and reporting, as required
  • To adhere strictly to established quality standards, essential for on-going activities
  • Drafting and review of SOPs and batch records
  • Provide accurate record keeping at all times

 

CRITERIA:

  • BSc or MSc in relevant discipline, with experience working in a laboratory environment
  • Commercial/industry experience is preferred but not essential

 

Desirable:

  • Culturing and transfection of mammalian cell lines (CHO, HEK)
  • Purification of recombinant proteins (PrA, AEX, SEC)
  • Optimisation of cell culture processes
  • Characterisation of proteins via HPLC, ELISA, SDS-PAGE

 

COMPANY BENEFITS:

25 days Annual Leave plus Bank Holidays, Pension with matched employer contribution to 7%, Health Insurance, Group Life Cover, Child Care Voucher Scheme, Glasses Vouchers and a friendly working environment in a small and expanding company.

 

JOB LOCATION

We have offices in the UK and USA. This role will be located at The Oxford Science Park, just 4 miles south east of Oxford, with parking and good public transport links from Oxford. Our UK office address is: Oxford Genetics Ltd, Medawar Building, The Oxford Science Park, Oxford, OX4 4GA.

 

HOW TO APPLY

Candidates must be eligible to work in the United Kingdom without sponsorship.

Please send a CV. Your CV should include evidence that demonstrates how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks. Your application will be judged on the basis of how you demonstrate that you meet the selection criteria stated in the job description.

 

DIVERSITY AND EQUALITY OF OPPORTUNITY

We provide all our staff with a welcoming and inclusive workplace that enables and empowers everyone to develop and deliver professional excellence.  We recognise diversity is vital for innovation and creativity and value each individual’s contribution. Entry into employment with Oxford Genetics and further progression will be determined by personal merit and the application of criteria related to the duties of the role. The ability to perform the role will be the primary consideration on entry into employment and to successfully pass probation.

 

PRE EMPLOYMENT SCREENING

The appointment of the successful candidate will be subject to standard pre-employment screening, as applicable to the post. This will include right-to-work in the UK, proof of identity, references and health assessment.

 

To apply for the position then please send a cover letter and CV to recruitment@oxgene.com