Scientist - AAV Production

 

JOB TITLE: Permanent
HOURS: Full time
SALARY: £28,000 – £38,000/pa, dependent on experience

 

ABOUT OXFORD GENETICS:

Oxford Genetics, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems.

We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford. We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists, engineers and technicians to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do – join us and contribute to this exciting journey!

 

ROLE OVERVIEW:

The Scientist - AAV Production will manage an internal function for the generation and characterisation of AAV vectors for both in-vitro and in-vivo applications (non-GMP). The appointee would work to expand this service within the company and would then be responsible for its operational delivery working with technician colleagues.

This function would sit within the AAV Vector Group, which addresses both viral vector engineering and novel-bioproduction methodologies and works with a number of academic and industry collaborators. Oxford Genetics intends to further build its expertise over the next 6-12 months in the Viral Therapeutics field, predominantly around Lentiviral, AAV and Adenoviral vectors.

Prior experience in generating and characterising AAV vectors is essential. Relevant techniques (see next section) include plasmid preparation, transfection (hyperflask/stack, cell factories, suspension), harvest/clarification, purification by iodixanol, CsCl, affinity, IEX, and characterisation by qPCR, ELISA, Western blot.

 

KEY RESPONSIBILITIES:

  • Work closely with internal and external stakeholders to define project goals and deliverables, in line the planned project objectives
  • To line manage and train junior staff in appropriate techniques
  • Provide project summaries and reporting, as required
  • Support line manager with customer interactions, and in ensuring smooth running of the group.
  • To adhere strictly to established quality standards, essential for on-going activities
  • Drafting and review of SOPs and batch records
  • Provide accurate record keeping at all times

 

CRITERIA:

  • BSc or MSc in relevant discipline, with considerable relevant experience in a production environment (>2 years minimum).
  • Experience working in a commercial/industry environment is preferred but not essential

 

Essential:

  • Extensive track record of handling adherent cell lines in multiple formats (multiwell plates, hyperflasks/stacks, cell factories)
  • Experience in production and characterisation of a range of AAV serotypes, and in implementation of best-practices for related processes
  • Good experience carrying out and utilising analytical techniques for vector characterisation

 

Desirable:

  • Handling and transfection of suspension cell lines
  • Optimisation and implementation of downstream processes for viral vectors
  • Analytical techniques for genetic characterisation of viral particles

 

COMPANY BENEFITS:

25 days Annual Leave plus Bank Holidays, Pension with matched employer contribution to 7%, Health Insurance, Group Life Cover, Child Care Voucher Scheme, Glasses Vouchers and a friendly working environment in a small and expanding company.

 

JOB LOCATION

We have offices in the UK and USA. This role will be located at The Oxford Science Park, just 4 miles south east of Oxford, with parking and good public transport links from Oxford. Our UK office address is: Oxford Genetics Ltd, Medawar Building, The Oxford Science Park, Oxford, OX4 4GA.

 

HOW TO APPLY

Candidates must be eligible to work in the United Kingdom without sponsorship.

Please send a CV. Your CV should include evidence that demonstrates how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks. Your application will be judged on the basis of how you demonstrate that you meet the selection criteria stated in the job description.

 

DIVERSITY AND EQUALITY OF OPPORTUNITY

We provide all our staff with a welcoming and inclusive workplace that enables and empowers everyone to develop and deliver professional excellence.  We recognise diversity is vital for innovation and creativity and value each individual’s contribution. Entry into employment with Oxford Genetics and further progression will be determined by personal merit and the application of criteria related to the duties of the role. The ability to perform the role will be the primary consideration on entry into employment and to successfully pass probation.

 

PRE EMPLOYMENT SCREENING

The appointment of the successful candidate will be subject to standard pre-employment screening, as applicable to the post. This will include right-to-work in the UK, proof of identity, references and health assessment.

 

To apply for the position then please send a cover letter and CV to recruitment@oxgene.com