Senior Scientist - Cell Line Development

 

JOB TYPE: Permanent
START DATE: Open
HOURS: Full time
SALARY: Competitive, dependent on experience

 

Oxford Genetics, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford. 

We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do – join us and contribute to this exciting journey!

 

Role Overview:

The Senior Scientist – Cell Line Development will be involved in both internal platform development and commercial projects, focusing on setting up and operationally leading an internal CHO-based cell line development platform for manufacture of therapeutic proteins.  Prior experience in development of cell lines for protein manufacture, and an understanding of methodologies for the optimisation of cell growth conditions, genetic manipulation of cell lines, and product quality attributes (PQAs) would be highly advantageous. This role will interface extensively with colleagues in the protein engineering, expression and process development

 

KEY RESPONSIBILITIES:

  • Work closely with internal and external stakeholders to define project goals and deliverables, in line the planned project objectives
  • To keep up-to date with the scientific literature and developments in the field
  • Set an example to other colleagues, and to train junior staff in appropriate techniques
  • Provide project summaries and reporting, as required
  • Promote and suggest implementation of new methods, technologies and processes to ensure best practice
  • Support line manager with customer interactions, and in ensuring smooth running of the group.
  • To adhere strictly to established quality standards, essential for on-going activities
  • Provide accurate record keeping at all times

 

MINIMUM QUALIFICATIONS OR EXPERIENCE NEEDED:

  • MSc or Ph.D in relevant discipline (Biotechnology, Genetics, Molecular Biology, Biochemistry)
  • Experience working in a commercial/industry setting relevant to the role (>2 years) is essential

 

PREFERRED SKILLS AND ABILITIES:

  • Extensive experience with handling of mammalian suspension cell lines, including generating stable, clonal lines.
  • Experience with Flow cytometry/FACS
  • Genetic characterisation of cell lines via qPCR/ddPCR
  • Generation of optimised genetic constructs for protein expression
  • Good knowledge of key assays to assess product quality attributes (HPLC, ELISA, MS)  
  • Knowledge of GLP, cGMP and/or other relevant quality systems
  • Highly developed interpersonal, written and verbal skills, including the ability to give presentations and to speak to groups
  • Excellent organizational and decision making skills
  • Strong time management skills with the ability to prioritize tasks, and work under pressure

 

COMPANY BENEFITS:

25 days Annual Leave plus Bank Holidays, Pension with matched employer contribution to 7%, Health Insurance, Group Life Cover, Child Care Voucher Scheme, Glasses Vouchers and a friendly working environment in an exciting and expanding young company.

 

JOB LOCATION

We have offices in the UK and USA. This role will be located at The Oxford Science Park, just 4 miles south east of Oxford, with parking and good public transport links from Oxford. Our UK office address is: Oxford Genetics Ltd, Medawar Building, The Oxford Science Park, Oxford, OX4 4GA.

 

HOW TO APPLY

Candidates must be eligible to work in the United Kingdom without sponsorship.

Please send a CV. Your CV should include evidence that demonstrates how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks. Your application will be judged on the basis of how you demonstrate that you meet the selection criteria stated in the job description.

 

DIVERSITY AND EQUALITY OF OPPORTUNITY

We provide all our staff with a welcoming and inclusive workplace that enables and empowers everyone to develop and deliver professional excellence. We recognise diversity is vital for innovation and creativity and value each individual’s contribution. Entry into employment with Oxford Genetics and further progression will be determined by personal merit and the application of criteria related to the duties of the role. The ability to perform the role will be the primary consideration on entry into employment and to successfully pass probation.

 

PRE EMPLOYMENT SCREENING

The appointment of the successful candidate will be subject to standard pre-employment screening, as applicable to the post. This will include right-to-work in the UK, proof of identity, references and health assessment.

 

 

To apply for the position then please send a cover letter and CV to recruitment@oxgene.com