CRISPR-Cas9 technology has revolutionized the field of genome editing and has enabled high efficiency mammalian
cell engineering for a variety of downstream applications. Oxford Genetics has developed an automated, streamlined
platform for the generation of genome modified cell lines. Each step of the workflow has been optimized
and quality-assured for high throughput and large-scale demands of creating engineered cell lines.
Create a modified cell line to analyze the loss of function of a single-gene knock-out, investigate combinatorial effects, pathway redundancy, and epistatic relationships via multigene knock-out, and study the role of genes in disease models, cell processes, and drug responses.
Create a modified cell line to analyse the effect of the generation of a chromosomal fusion or other macro rearrangements.
Create a modified cell line that introduces gain-of-function and loss-of function mutations in endogenous genes to study the impact of SNPs or somatic mutations, or generate conditional alleles by the inclusion of LoxP sites.
Create a modified cell line that fuses endogenous genes or genomic loci to fluorescent proteins and epitope tags, such as His or FLAG, to enable downstream analysis.