About Oxford Genetics

Oxford Genetics, a leader in synthetic biology, is a specialized contract research organization offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications.

A unifying theme across the portfolio is expertise in DNA design, expression system optimization, cell line development and engineering of viral delivery systems. We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford.

We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do & join us and contribute to this exciting journey!

Fixed duration: Permanent
Wage: £30,000 – £40,000
Hours: Full-time


Role Overview

The appointee will be involved in a range of internal platform development and commercial projects, focusing on establishing process development capabilities for the production of both therapeutic proteins and viral vectors for gene therapy applications. Oxford Genetics has a number of on-going programmes in this area, and multiple government supported grant awards, which the recipient will contribute towards.

The Process Development Scientist (Downstream) will work together with Scientist colleagues to specify and implement scalable processes for primary recovery and product purification. The position will involve extensive interaction with both internal and external stakeholders, and the ability to show commitment to scientific development and innovation are considered essential.

Prior experiencing of using relevant techniques, including TFF, ultracentrfugation and AKTA-based chromatography (Affinity, IEX and SEC) is absolutely required, as is experience in developing and implementing associated process for mammalian production systems. The position will work closely with the Cell Line Development, Upstream Process and Analytical teams, and will report to the Chief Technology Officer.


Key Responsibilities

  • Lead, plan and conduct primary recovery and purification experiments including use of statistical approaches for process design and specification (DOE, QbD)
  • To support technology transfer activities for commercial manufacturing
  • To work closely with internal and external stakeholders to define project goals and deliverables, in line with planned project objectives
  • To keep up to date with the scientific literature and developments in the field
  • Set an example to other colleagues, and to train and mentor junior staff
  • Perform data analysis, author Standard Operating Procedures and write technical reports
  • Support and contribute to protection and assessment of intellectual property
  • Promote and suggest implementation of new methods, technologies and processes to ensure best practice
  • To ensure established quality standards are strictly adhered to, across all on-going activities

Criteria

  • A Ph.D, DPhil or MSc in Chemical Engineering, Biochemical Engineering, Cell Biology or Biochemistry, along with several years industry experience applicable to the role.
  • Extensive knowledge of subject area, and ideally a strong network within academic and industry groups
  • An engineering mindset – good ability to utilise statistical approaches (in particular Design of Experiments) to optimize processes and procedures
  • Prior experience of using TFF and AKTA systems
  • Experience in implementing downstream processes for mammalian systems for both for protein (desirable) and viral vector (essential) production
  • Highly developed interpersonal, written and verbal skills, including the ability to give presentations and to speak to groups
  • High-level attention to detail
  • Ability to work under demanding conditions, and to cope with shifting priorities

Main Company Benefits:

25 days Annual Leave plus Bank Holidays, Pension with matched employer contribution to 7%, Health Insurance, Group Life Cover, Child Care Voucher Scheme, Glasses Vouchers and a friendly working environment in an exciting and expanding young company.


Job Location

We have offices in the UK and USA. This role will be located at The Oxford Science Park, just 4 miles south east of Oxford, with parking and good public transport links from Oxford. Our UK office address is: Oxford Genetics Ltd, Medawar Building, The Oxford Science Park, Oxford, OX4 4GA.


How To Apply

Candidates must be eligible to work in the United Kingdom without sponsorship.

Please send a CV. Your CV should include evidence that demonstrates how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks. Your application will be judged on the basis of how you demonstrate that you meet the selection criteria stated in the job description.


Diversity And Equality Of Opportunity

We provide all our staff with a welcoming and inclusive workplace that enables and empowers everyone to develop and deliver professional excellence.

We recognize diversity is vital for innovation and creativity and value each individual’s contribution. Entry into employment with Oxford Genetics and further progression will be determined by personal merit and the application of criteria related to the duties of the role. The ability to perform the role will be the primary consideration on entry into employment and to successfully pass probation.


About Oxford Genetics

Oxford Genetics, a leader in synthetic biology, is a specialized contract research organization offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications.

A unifying theme across the portfolio is expertise in DNA design, expression system optimization, cell line development and engineering of viral delivery systems. We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford.

We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do – join us and contribute to this exciting journey!


Pre-Employment Screening

The appointment of the successful candidate will be subject to standard pre-employment screening, as applicable to the post. This will include right-to-work in the UK, proof of identity, references and health assessment.

Apply