Gene synthesis is the process of manufacturing DNA sequences de novo by chemical approaches. The expansion in gene synthesis services is enabling a revolution in biomedical research; allowing us to test more variables, more quickly. However, the majority of gene synthesis service providers are limited in the plasmid vectors they are able to synthesise genes into. At Oxford Genetics we have developed the world’s largest collection of standardised LEGO-like DNA plasmids (called SnapFastTM), allowing gene synthesis to be ordered in any of over 3000 vectors using any restriction site(s). 

Benefits of Working with Oxford Genetics

Our SnapFastTM plasmid vector system covers a diverse set of applications, including:

  • Mammalian, bacterial, and yeast protein expression
  • CRISPR Guide and Cas9 expression
  • Viral vectors including AAV, lentiviral and Adenoviral vectors
  • In vitro transcription vectors
  • Reporter gene plasmids and stable cell line engineering

Service Information

Our streamlined service offers timely and dependable results, giving you the flexibility to focus on other research priorities. Simply submit your nucleotide sequences through our Plasmid Builder tool and we will deliver it exactly as ordered. 

By ordering gene synthesis from Oxford Genetics you will also have access to our dedicated online project portal, which will provide regular updates on your project throughout the synthesis process, providing peace of mind throughout.  

Priority Synthesis

Our gene synthesis priority service is a robust service that delivers over 95% of projects on time. The typical turnaround time for priority gene synthesis is 20 working days. In some instances where the gene sequences are particularly complex or repetitive additional time may be required. This service has two price points. The lower price point covers normal gene sequences up to 3.2Kb. For more complex sequences and repetitive sequences a higher price per base pair may be charged. 

Next Generation Synthesis

For gene synthesis orders over 20 genes, and where all genes are above 350 base pairs and below 3Kb, we provide the option of a reduced cost using next generation synthesis. This service typically has a longer turn around time (20-30 working days)

Service Vector Synthesis Length Minimum Genes Optimization Quantity Turnaround Cost


pUC57-Amp or Kan 250bp-5Kb 1 Optional 5 ug Under 20 days Priced per base pair. Genes over 3.Kb incur an additional charge.

Priority Plus

Any Oxford Genetics Plasmid 250bp-5Kb 1 Optional 5 ug Under 20 days Priced per base pair, plus the catalogue vector on first purchase.

Next Generation 

Any Oxford Genetics Plasmid 350bp-3.2Kb 20 @ 350bp Optional 500 ng 25 days Priced per base paid with a vector preparation fee



Additional Services

In addition to standard DNA synthesis, the following additional services are also available.


Gene Optimization

  • Coding sequence optimization of your gene of interest using our proprietary algorithms and in-house expertise.
  • High-throughput design and data processing (simultaneous optimisation of >1000 genes).
  • Modification of any DNA parameter, including balancing base composition, removal of palindromic and direct repeats, removal of restriction sites and consensus splice sites. 

Plasmid Optimization

  • Expression construct optimization, including Introduction of alternative promoter sequences; inclusion of optimal sequences in the 5’ UTR, 3’ UTR and poly-adenylation regions; choice of Kozak and stop codons; inclusion of exogenous genes to increase protein yield.