Blogs

 

1

March
2018

Influenza, the difficulty of producing effective vaccines, and recent innovation in flu vaccines

There are several metrics by which the severity of a flu season is officially measured: the number visits to the doctor for flu-like symptoms, the number of flu-related hospitalizations, and, of course, the number of flu-related deaths. By every one of these metrics, the current flu season is turning out to be a pretty bad one both in Europe and, even more so, in the U.S.

 

 

 

1

March
2018

DNA origami: from novelty item to novel applications

There’s nothing mysterious about the name given to the practice known as DNA origami. The technique is exactly what it sounds like: the art of folding DNA. There is, however, a great deal of scientific intrigue about the practice, which may be on the verge of a big payout.

 

 

 

5

February  2018

Our appetite for stem cells might be getting them in trouble

After a long and rocky road, stem cell technology is finally starting to shine. But stem cells’ newfound reputation as a miracle curative has enabled irresponsible actors and prompted regulation that may set the field back.

 

 

 

12

December 2017

Genome Editing: One Small Needle for Brian, One Giant Injection For Gene Therapy

We take a look at the ground-breaking treatment which saw a gene being directly edited in vivo, rather than modifying a patients' cells outside of the body. The doctors and the biotech company (Sangamo Therapeutics) that developed the technology are as confident as they can be that the treatment will be safe.

 

 

 

12

December 2017

Gene Therapy for Heart Disease. Is there promise for other types of heart failure?

Advances in angiogenic gene therapy suggest that physicians might soon be able to treat heart disease by stimulating the growth of new vascular tissue where it is most needed. But is there promise for treating other types of heart disease, such as arrhythmias or congenital heart failure?

 

 

 

2

October 2017

The trouble with (and necessity of) genomic biobanking

As tools like these are refined and perfected, we are looking at a near future where the greatest barrier to their implementation will have little to do with their reliability, but rather our limited knowledge of how and where to apply them.

 

 

 

1

October 2017

A solution to the Viral Production Bottleneck for Cell and Gene therapy

We are now a few months from the release of Oxford Genetics first Virus packaging cell line – cell lines with viral packaging genes inserted in the genome to allow simplified virus production processes.

 

 

 

12

September 2017

Bootstrapping a Biotech: The unlikely tale of how we became a market leader

I had an idea, well kind of a half-baked idea, to create a biotechnology company that worked with DNA a little differently. The only problem was, I had no money.

 

 

 

8

September 2017

 

Development in CRISPR technology moves rapidly, your library should too

As developments in CRISPR technology gather pace many commercial providers rely on historical libraries created using dated design parameters. This may limit the library to particular existing applications but what if you could invest in a custom library that has few limits in terms of its flexibility and agility?

 

 

 

13

June 2017

 

Optogenetics: An Illuminating New Tool in Neuroscience

While this profession elicits disgusted groans from audiences, science has of late discovered a scenario in which algae and eyes in the same sentence might be a beneficial idea.

 

 

 

10

May 2017

 

Genetic Circuits: Reprogramming Biology

Science has long been a field driven by curiosity. In more recent history, pressure has escalated for science to offer not just new discoveries and ideas, but ways to implement them for the betterment of society, a role in which engineers excel.

 

 

 

10

May 2017

 

Human 2.0: Accident and Emergency Only

The year is 2117, man has landed on Mars using a Tesla powered hydrogen fuel cell and hospitals only cater for births, accidents & emergencies. Why do I say this?

 

 

 

3

April 2017

 

Sequence Me: The Genomic Arms Race

At the turn of the century The Human Genome Project and Celera Genomes were pitted against each other to become the first group to ever sequence the complete human genome, but while their rivalry held the spotlight another organization was quietly becoming the largest genomics enterprise in the world.

 

 

 

1

March 2017

 

CAR T-cell Drug Makers Race Toward FDA Approval

There has been some very promising immunotherapy research in recent years, additional cancer fighting tools may soon be included in the broader oncology arsenal.

 

 

 

6

February 2017

 

DNA Data Storage: Nature Does It Better!

Now, the biotech community is recognizing that nature does one more thing better than human innovation has thus far been able to: data storage.

 

 

 

1

February 2017

 

Gene Therapy: Why It Matters

Promising strides have been made in gene therapy and for millions of people who suffer from genetic disorders, the hope for a normal life may soon become a real possibility.

 

 

 

16

January 2017

 

The Century of Genome Engineering

From the mice whose cataracts were cured to the first-ever undertaking to edit the DNA of human embryos, we take a look at The Century of Genome Engineering.

 

 

 

12

January 2017

 

The Great CRISPR Custody Battle.

One of the great genetic engineering game changers is currently embroiled in a heated custody battle.

 

 

 

28

November 2016

 

Is a Win for Trump a Win for Pharma?

Where do future uncertainties lie for the pharmaceutical industry? We take a look at the primary factors at play.

 

 

 

15

November 2016

 

A systematic approach to maximising the manufacturing quantity and transduction activity of lentiviral vectors

Two factors currently limiting wider development of these approaches are the yield and scalability of lentiviral production systems, and relatively low infectivity in T cells.

 

 

 

12

October 2016

 

Building muscles and looking fantastic

Making proteins in mammalian expression systems can be a painful experience so we have come up with a few ways to maximise your protein expression systems.